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Revealing Novel Compounds in the Biochemical Hemp Haystack Using High-Resolution Ion Mobility

Author(s)

Rachel Harris, Frederick G. Strathmann

Abstract

The search for effective therapeutic agents from natural extracts requires accurate identification of novel compounds amid complex chemical diversity. High-Resolution Ion Mobility (HRIM) emerges as a promising solution to overcome challenges in sample analysis. This study explores HRIM's utility by analyzing 28 cannabinoids in Cannabis sativa. The combination of HRIM with chromatography and mass spectrometry enables enhanced separation of isomers, increased sensitivity, and additional collision cross-section data. The application of HRIM opens new possibilities for studying natural extracts, enhancing characterization, and streamlining the drug development process.

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