Tackling the Glycan Isomer Challenge for your Biotherapeutics with MOBIE

N-linked glycosylation is a critical influencer of pharmacological function, safety and efficacy.  As minor changes to production processes can influence both glycan structure and composition, glycans must be monitored. However, characterization of N-linked glycosylation is analytically challenging due to innate glycan microheterogeneity. Herein we report the use of the MOBIE high-resolution ion mobility platform from to improve N-linked glycan analysis and demonstrate applicability for profiling complex glycan isomeric mixtures.

What can you expect to learn by watching?

• What is HRIM
• How can MOBIE improve analysis of N-linked Glycans
• Benefits of incorporating HRIM-MS into glycan analysis workflows