TIDES 2024

Ion mobility (IM) interest and implementation has grown in pharmaceutical industry over the last 10 years. IM technology can be hyphenated with traditional LC-MS providing an orthogonal separation to aid in the identification of isomeric modified peptides. A review of commercially available IM with a case study to demonstrate how structures for lossless ion manipulation (SLIM) high resolution ion mobility (HRIM) can be leveraged to study peptide therapeutics.