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High Resolution Ion Mobility-Mass Spectrometry (HRIM-MS) for Rapid Resolution of Peptides Containing Deamidation and Isoaspartic Acid

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High Resolution Ion Mobility-Mass Spectrometry (HRIM-MS) for Rapid Resolution of Peptides Containing Deamidation and Isoaspartic Acid

Author(s)

ndrew B. Dykstra, Heide Vitrac, Thomas Lubinsky, Ashli Simone, Iain Campuzano, and Pavel Bondarenko

Abstract

Chemical modifications of biological therapeutics are of utmost concern due to the potential of the seliabilities affecting the safety and/or efficacy of the molecule, and mass spectrometry plays a critical role in identifying and quantitating these species.

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High Resolution Ion Mobility-Mass Spectrometry (HRIM-MS) for Rapid Resolution of Peptides Containing Deamidation and Isoaspartic Acid

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