Ion Mobility Mass Spec - A 4th Dimension Gets More Information Faster Than Ever Before
Ion Mobility Mass Spec - A 4th Dimension Gets More Information Faster Than Ever Before
Christian Klein, PhD and Tom Doherty, PhD
Ion mobility is moving into the mainstream. In this webinar, you will learn about this technology and how it can address current problems in the characterization of complex biomolecules. The additional dimension of separation added by Ion Mobility allows one to detect different structural elements of molecules unseen by conventional mass spectrometry alone. This webinar will demonstrate unique capabilities in separation and analysis using a low-field drift-tube based separation with Collision-induced unfolding (CIU), and the novel SLIM (Structures for Lossless Ion Manipulations) technology with highest full spectrum Ion Mobility resolution by incorporating a 13m non-linear ion path into a benchtop instrument. Focusing on Biopharma applications, this webinar will show how Ion Mobility can be used to obtain an in-depth understanding of the most challenging analyses.
What can you expect to learn by watching?
- Principles of Ion Mobility and the separation by shape
- Collision induced unfolding (CIU) to understand protein stability and changes
- Fast separation and characterization of Glycans
- Ultra-high resolution Ion Mobility by miniaturized SLIM technology
- Separation of deamidated peptides using high-resolution Ion Mobility
- Benefit of adding a new separation dimension to MS workflows