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Native HRIM MS Eliminates Chemical Noise and Enables Quaternary Structure Analysis of ALS associated SOD1 Proteoforms

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Native HRIM MS Eliminates Chemical Noise and Enables Quaternary Structure Analysis of ALS associated SOD1 Proteoforms

Author(s)

Md Amin Hossain, Brandon C. Miller, Roman Manetsch, Jared R. Auclair, Jeffrey N. Agar

Abstract

Ion mobility mass spectrometry is particularly beneficial to identify changes in tertiary and quaternary structure, such as the role of metals and drug candidates in stabilizing SOD 1 variants We introduce native IM MS methods using several commercially available sources and extend the upper m/z limit for commercial SLIM.

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Native HRIM MS Eliminates Chemical Noise and Enables Quaternary Structure Analysis of ALS associated SOD1 Proteoforms

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