Tackling the Peptide Isomer Impurity Challenge with High-Resolution Ion Mobility Mass Spectrometry

Tackling the Peptide Isomer Impurity Challenge with High-Resolution Ion Mobility Mass Spectrometry

Julie Wushensky

Overall, the combination of RPLC and MOBIE HRIM enables confident separation, detection, and relative quantification of difficult-to-analyze isobaric and isomeric peptides reproducibly by eliminating the reliance on MS/MS fragmentation pattern.