MOBILion Systems Demonstrates Integration of SLIM Technology with Orbitrap Technology Yielding Sensitivity Gains

MOBILion Systems, Inc., a life science tools and instrumentation company, presented at the Human Proteome Organization (HUPO) World Congress the first of its kind proof of concept integrating their SLIM (structures for lossless ion manipulation) technology with the Thermo Scientific™ Orbitrap Exploris™ 480 mass spectrometer.

A project involving MOBILion and Thermo Fisher aims to address the industry's current limitations in sensitivity, including challenges in detecting low abundance analytes. In a co-authored presentation at the HUPO 2022 World Congress in Cancún, Mexico last month, the research teams demonstrated the use of SLIM technology to enhance signal intensities on the Orbitrap Exploris 480 mass spectrometer system up to 200x. This signal increase was shown for low abundance peptide signals typically observed in proteomic workflows. The ability to reliably detect and identify peptides and proteins from single isolated cells represents the next frontier in proteomics that warrants an ultra-high sensitivity technological solution.