SLIM-based HRIM-MS: the future of challenging separations

High Resolution Ion Mobility Mass Spectrometry (HRIM-MS) based on Structures for Lossless Ion Manipulation (SLIM) has emerged as a promising separation strategy for identifying the most challenging clinically significant molecules, including isomers, lipids, glycans and peptides.

In this interview, the inventor of SLIM, Dr Richard D. Smith, Director of Proteomics Research at Pacific Northwest National Laboratory (PNNL), takes Dr Kevin Robinson through the development of SLIM technology and how his team achieved its breakthrough of turning ions around corners.