Use of High-Resolution Ion Mobility for PFAS Isomer Separation

Use of High-Resolution Ion Mobility for PFAS Isomer Separation

Frederick G. Strathmann, Alan McKenzie-Coe, Josh A. McBee

The growing concern over the toxicological significance of Per- and Polyfluoroalkyl Substances (PFAS) necessitates advanced analytical methods for their accurate identification and separation. This study demonstrates the utility of High-Resolution Ion Mobility (HRIM) in PFAS isomer analysis using LC-HRIM-HRMS. The combination of chromatography, mass spectrometry, and HRIM provides enhanced separation of linear and branched forms of PFAS, enabling the detection of previously unidentified compounds. HRIM offers a powerful approach to tackle the challenges of PFAS analysis and contributes to a deeper understanding of complex sample compositions.